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Selected articles

Mapping temperature-sensitive mutations at a genome-scale to engineer growth-switches in E. coli.

Schramm T, Lubrano P, Pahl V, Stadelmann A, Verhülsdonk A, Link H (2023) 

Molecular Systems Biology, e11596, Journal Link

Systematic analysis of in-source modifications of primary metabolites during flow-injection

time-of-flight mass spectrometry

Farke N, Schramm T, Verhülsdonk A, Rapp J, Link H (2023) 

Analytical Biochemistry 664, Journal Link

Homeostasis of the biosynthetic E. coli metabolome

Radoš D, Donati S, Lempp M, Rapp J, Link H (2022) 

iScience, 104503, Journal Link

Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli

Wang CY*, Lempp M*, Farke N, Donati S, Glatter T, Link H (2021) 

Nature Communications 12, 4929. *equal contribution, Journal Link

Multi-omics analysis of CRISPRi-knockdowns identifies mechanisms that buffer decreases of enzymes in E. coli metabolism 

Donati S*, Kuntz M*, Pahl V, Farke N, Beuter D, Glatter T, Gomes-Filho JV, Randau L, Link H (2021) 

Cell Systems 12, 1-12. *equal contribution, Journal Link

High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli

Schramm T, Lempp M, Beuter D, Sierra SG, Glatter T, Link H (2020) 

Metabolic Engineering 60, 14-24. Journal Link

Systematic identification of metabolites controlling gene expression in E. coli

Lempp M, Farke N, Kuntz M, Freibert S, Lill R, Link H (2019) 

Nature Communications 10, 4463. Journal Link

CRISPRi-based downregulation of transcriptional feedback improves growth and metabolism of arginine overproducing E. coli

Sander T, Wang CY, Glatter T, Link H (2019) 

ACS Synthetic Biology 8, 1983-1990. Journal Link

Allosteric feedback inhibition enables robust amino acid biosynthesis in E. coli by enforcing enzyme overabundance

Sander T, Farke N, Diehl C, Kuntz M, Glatter T, Link H (2019)

Cell Systems 8, 1-10. Journal Link

Selective enrichment of slow-growing bacteria in a metabolism-wide CRISPRi library with a TIMER protein

Beuter D, Gomes-Filho J, Randau L, Díaz-Pascual F, Drescher K, Link H (2018)

ACS Synthetic Biology 7, 2775–2782. Journal Link

Time-Optimized Isotope Ratio LC-MS/MS for High-Throughput Quantification of Primary Metabolites.

Guder JC , Schramm T, Sander T, Link H (2017)

Analytical Chemistry 89 (3): 1624–1631. Journal Link

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