Alejandra Alvarado - Postdoc
"Hi there! I spend my time in the Link Lab understanding interactions between relevant cellular metabolites and transcription factors in bacteria by integrating metabolome and transcriptome data. Why, you ask? Understanding the influence of metabolism on gene expression and regulation opens tons of possibilities to develop tools and strains that can help us make useful compounds. I am also interested in the role of metabolism in the establishment of synergistic and antagonistic microbial interactions, which are very common in microbial communities, for instance in the human gut environment."
Michelle Kuntz - PhD Student
Hi, I am Vanessa and I am interested in climate change and CO2 fixation. For this reason, I am investigating the metabolism of an engineered E. coli that grows solely on CO2 as carbon source and formate as energy source. In my PhD I try to improve this autotrophic E. coli to enable the production CO2 based chemicals, such as amino acids. To achieve this, I will analyse the metabolome to answer important questions about metabolism and physiology of this strain. In close collaboration with the Milo Lab from the Weizmann institute of Science (Israel) we try to close knowledge gaps and improve the growth rate that currently limit the application of this strain.
Niklas Farke - PhD Student
"Prior to starting my Ph.D. as computational biologist in Hannes group I obtained my Bachelor's and Master's degrees in Molecular Biotechnology and Industrial Biotechnology at the TU Munich. My research interest is the systems biology of metabolism, especially discovering and comprehending metabolic regulations. To this end, I perform many computational tasks including the analysis of raw mass spectrometry data, mathematical modelling of metabolic networks and machine learning with multi-omics data. Most of the time, I collaborate closely with my wet lab colleagues."
Paul Lubrano PhD Student
"I am a French PhD student who studied Biotechnology in Paris (Sup'Biotech). My experience encompasses working in both academic (CEA, MNHN, France) and industrial (Biosyntia, Denmark) sectors mainly in the engineering of micro-organisms for industrial biotechnology. I also participated in the iGEM competition in 2017 (iGEM IONIS). My current project relies on the multi-omics study of essential processes like translation and transcription in Escherichia coli. I hope to develop industrial and medical applications with such approach."
Thorben Schramm - PhD Student
"Dynamic control of cellular metabolism and growth is important for innovative bioprocess strategies, e.g. for two-stage processes, and for studying the regulation of metabolism. In my research, I use temperature-sensitive enzymes to achieve the dynamic control of metabolism and developed a two-stage bioprocess for citrulline production in 1-L bioreactors (Schramm et al. 2020). On the hunt for temperature-sensitive enzymes, I generate large strain libraries with different contemporary cloning techniques. Combining a single-cell growth rate reporter (TIMER) with flow cytometry, the libraries are screened in high-throughput for the desired temperature-sensitive mutants. With the cutting-edge quantitative LC-MS/MS method (Guder et al. 2017) that we developed, I investigate my production strains but also the strains of our collaborators (Boecker et al., 2019)."
Johanna Rapp - Postdoc
"As a PostDoc in the Link Lab, I take care of our two mass spectrometers – a high resolution Quadrupole-TOF and a Triple Quadrupole. If you are interested to measure the metabolome of your organisms, please contact me.
Before, I started my PostDoc, I studied Technical Biology at the University of Stuttgart. After that, I obtained my PhD in Microbiology at the University of Tuebingen."